Publications by authors named "O H Schmitt"
Article Synopsis
- Experimental rat models of stroke and hemorrhage are critical for studying cerebrovascular disease, revealing how functional impairment relates to changes in brain connectivity.
- The study utilized two types of stroke models and one hemorrhage model to assess motor skills and memory, while analyzing neuronal activation in the hippocampus.
- Findings showed that the extent and location of brain injuries correlate with functional impairments, and remote brain regions exhibited significant connectivity changes affecting learning and memory abilities.
Positive human-animal interactions (HAIs) can be intrinsically rewarding and facilitate positive human-animal relationships. However, HAI paradigms vary across studies, and the influence of different interaction paradigms on the animal's response has been overlooked. We compared the behavioural responses of pigs (n = 28) individually tested with two types of gentle tactile interactions with a familiar human: 'free form (FF)' where the pig could voluntarily approach and interact as they normally would, and 'imposed contact (IC)' where the human imposed tactile contact on the pig according to a standardised protocol.
View Article and Find Full Text PDFBackground: Niemann-Pick disease type C1 (NPC1, MIM 257220) is a heritable lysosomal storage disease characterized by a progressive neurological degeneration that causes disability and premature death. A murine model of displays a rapidly progressing form of Npc1 disease, which is characterized by weight loss, ataxia, and increased cholesterol storage. mice receiving a combined therapy (COMBI) of miglustat (MIGLU), the neurosteroid allopregnanolone (ALLO) and the cyclic oligosaccharide 2-hydroxypropyl-β-cyclodextrin (HPßCD) showed prevention of Purkinje cell loss, improved motor function and reduced intracellular lipid storage.
View Article and Find Full Text PDFGenomic sequences of A cluster phages LBerry, Pembroke, and Zolita.
Microbiol Resour Announc
August 2024
Article Synopsis
- LBerry, Pembroke, and Zolita are newly identified bacteriophages that infect a specific bacterium, mc²155.
- LBerry and Pembroke are grouped in cluster A3, indicating they have similar gene content, while Zolita belongs to cluster A5.
- LBerry and Pembroke share 99% genetic similarity with the phages Anaysia and Caviar, and Zolita is 99% similar to the phage SydNat.
Article Synopsis
- - This paper reviews various techniques for predicting the progression of multiple sclerosis (MS), categorizing existing methods into clinical, radiological, biological, and AI-based markers, while highlighting the need for a comprehensive evaluation of their strengths and weaknesses.
- - The authors propose a new predictive approach combining computational models with established connectomes, specifically using the Hodgkin-Huxley model, which takes into account key properties altered in MS, like neuronal connection weights and signaling rates.
- - The study aims to model neuronal signal propagation under MS conditions by adjusting conduction parameters in a small network and comparing the simulated results against a control, ultimately providing insights into the dynamics affected by the disease.