Tryptophan Prevents the Development of Non-Alcoholic Fatty Liver Disease.

Purpose: The main aim of this research is to study the protective effects of tryptophan on the histomorphological and biochemical abnormalities in the liver caused by a high-calorie diet (HCD), as well as its ability to normalize mitochondrial functions in order to prevent the development of non-alcoholic fatty liver disease (NAFLD).

Methods: The study was conducted in male Wistar rats aged 3 months at the start of the experiment. Control animals (group I) were fed a standard diet.

[The effect of altered oxygen partial pressure on the resisitance to hypoxia and expression of oxygen-sensitive genes in Drosophila melanogaster].

As a result of resistance test to hypoxia of Drosophilas melanogaster of Oregon strain, we identified a high resistance (Group II) and low resistance (Group III) subpopulations of flies. Flies from groups II and III were incubated in a constant normobaric hypoxia (Po2=62-64 mm Hg) for 10 generations. A highly resistant group (Group IV) were exposed to a shortterm anoxia (Po,=1,5 mm Hg, 5 min) every generation.

[Dosed normobaric hypoxia as a non-medication approach of stimulation of physiological regeneration of liver parenchyma].

The investigation was devoted to studying the effects of different modes of dosed normobaric hypoxia on the changes in morphometric indexes of functional activity and physiological regeneration of liver parenchyma in young rats. It was shown, that in rats exposed to hypoxic gas mixture (10% O2), the amount of karyonucleus and binuclear hepatocytes, nucleocytoplasmic and nucleolar-nuclear correlation increased. The changes in these indexes appeared to be more intensive when dosed normobaric intermittent hypoxia was administered with alternation of deoxygenation and reoxygenation periods.

[Influence of food restriction on the biomechanical properties of the tibia in male rats of different age].

The changes of tibial bones biomechanical properties after 28 daily 40% declines of calorie content of feed and subsequent period of proceeding in a food ration were study in young and adult rats.28 day diminishing of calorie content of day's ration decline of bone mass, load capacity, stiffness, energy of elastic deformation of tibial bones. The indexes of biomechanics properties of bones were normalized after 28 daily period of proceeding in the ordinary ration of feed.

[Effect of oxygen deprivation on photosensitivity and thermostability of Drosophila].

There are certain distinctions in firmness to the high temperature and photo sensitiveness between highly and low steady to the hypoxia action of flies. Flies of line Conton-S after preadaptation to hypoxia acquired more firmness to the high temperature. Most of flies in line Uman, who are high-steady to the action of hypoxia, had positive phototaksis.