Reversal of elution order for profen acid enantiomers in normal phase LC on Chiralpak AD.

Enantiomeric separations of four 2-substituted propionic acid drugs and two related acids have been studied using normal phase liquid chromatography with amylose (tris 3,5-dimethylphenylcarbamate) coated on silica as support (Chiralpak AD). At standard conditions (i.e.

Supercritical fluid chromatography of metoprolol and analogues on aminopropyl and ethylpyridine silica without any additives.

Metoprolol and a number of related amino alcohols and similar analytes have been chromatographed on aminopropyl (APS) and ethylpyridine (EPS) silica columns. The mobile phase was carbon dioxide with methanol as modifier and no amine additive was present. Optimal isocratic conditions for the selectivity were evaluated based on experiments using design of experiments.

Packed column supercritical fluid chromatography of sodium stearyl fumarate aqueous suspension.

A method for the determination of sodium stearyl fumarate aqueous suspension is described. This straightforward method is based on homogenisation of the sample, dilution of a known aliquot with methanol to a suitable clear solution and mixing with an internal standard; (S)-naproxen. Separation and quantification is performed by packed column supercritical fluid chromatography on a commercial tartaric acid network polymeric column (tertbutylbenzoyl) with UV-detection at 214 nm.

Reversal of elution order for profen acid enantiomers in packed-column SFC on Chiralpak AD.

Enantiomeric separations of four 2-substituted propionic acid drugs have been studied using packed-column supercritical fluid chromatography (SFC) with amylose tris(3,5-dimethylphenylcarbamate) coated on silica as support (Chiralpak AD). Under standard conditions (i.e.