Publications by authors named "O Guzeloglu-Kayisli"
Article Synopsis
- - Uterine leiomyomas, affecting up to 80% of women, cause issues like abnormal bleeding, pelvic pain, and infertility, but their growth mechanisms are not well understood.
- - Research showed that uterine leiomyomas had lower levels of CD73 expression and adenosine compared to healthy myometrium, suggesting a link to tumor growth regulation.
- - Experiments indicated that adding adenosine or certain receptor agonists inhibited the growth of leiomyoma cells by promoting cell death and reducing key protein expressions, proposing new treatment approaches for these tumors.
Chorioamnionitis generates prostaglandin (PG) E and F, promoting fetal membrane rupture, cervical ripening, and uterine contractions. 15-Hydroxyprostaglandin dehydrogenase (HPGD) contributes to pregnancy maintenance by inactivating PGs. Herein, the role of decidual cells in the regulation of HPGD expression at the maternal-fetal interface was investigated.
View Article and Find Full Text PDFLeptin plays a crucial role in regulating energy homoeostasis, neuroendocrine function, metabolism, and immune and inflammatory responses. The adipose tissue is a main source of leptin, but during pregnancy, leptin is also secreted primarily by the placenta. Circulating leptin levels peak during the second trimester of human pregnancy and fall after labor.
View Article and Find Full Text PDFObjective: To study the effect of adenomyosis on the localized expression of the GATA binding proteins 2 and 6 (GATA2 and GATA6) zinc-finger transcription factors that are involved in proliferation of hematopoietic and endocrine cell lineages, cell differentiation, and organogenesis, potentially leading to impaired endometrial implantation.
Design: Laboratory based experimental study.
Setting: Academic hospital and laboratory.