Publications by authors named "O Gruselle"
Article Synopsis
- The study evaluated the efficacy and safety of the RSVPreF3 OA vaccine in seniors (60+) against RSV-related lower respiratory tract disease (RSV-LRTD) over two seasons following either one or two doses.
- It was a phase 3 blinded trial with 24,967 participants, showing an efficacy of about 67% for both one dose and two doses against RSV-LRTD and consistent results for severe cases.
- Revaccination after one year was well-tolerated, but it didn't significantly enhance efficacy compared to receiving just one dose.
Background: Respiratory syncytial virus (RSV) disease in older adults is undercharacterized. To help inform future immunization policies, this study aimed to describe the disease burden in Canadian adults aged ≥50 years hospitalized with RSV.
Methods: Using administrative data and nasopharyngeal swabs collected from active surveillance among adults aged ≥50 years hospitalized with an acute respiratory illness (ARI) during the 2012-2013, 2013-2014, and 2014-2015 influenza seasons, RSV was identified using a respiratory virus multiplex polymerase chain reaction test to describe the associated disease burden, incidence, and healthcare costs.
Background: Various case definitions of respiratory syncytial virus lower respiratory tract infection (RSV-LRTI) are currently proposed. We assessed the performance of 3 clinical case definitions against the World Health Organization definition recommended in 2015 (WHO 2015).
Methods: In this prospective cohort study conducted in 8 countries, 2401 children were followed up for 2 years from birth.
Unlabelled: Respiratory syncytial virus (RSV) causes substantial morbidity and mortality in infants and young children worldwide. Here we evaluated host demographic and viral factors associated with RSV disease severity in 325 RSV-infected infants under 1 year of age from 3 European countries during 2017-2020. Younger infants had a higher clinical severity (ReSViNET) score and were more likely to require hospitalization, intensive care, respiratory support, and/or mechanical ventilation than older infants (<3 months vs 3 to <6 months and 3 to <6 months vs ≥6 months).
View Article and Find Full Text PDFBackground: The true burden of lower respiratory tract infections (LRTIs) due to respiratory syncytial virus (RSV) remains unclear. This study aimed to provide more robust, multinational data on RSV-LRTI incidence and burden in the first 2 years of life.
Methods: This prospective, observational cohort study was conducted in Argentina, Bangladesh, Canada, Finland, Honduras, South Africa, Thailand, and United States.