Effect of interleukin-1 antagonist on growth of children with colchicine resistant or intolerant FMF.

Introduction: Familial Mediterranean Fever (FMF) is the most common monogentic autoinflammatory disease. FMF results from mutations in MEFV, which lead to a pro-inflammatory state and increased production of Interleukin 1 beta subunit (IL-1b) by myeloid cells. Despite the overall positive results obtained with anti-IL-1 agents in FMF patients, little is known about the long-term growth impact of these drugs in the pediatric population.

CAD in questions/answers Review of the literature.

Generalization of breast screening programs requires an efficient double reading of the mammograms, which allows reduction of false-negative rate, but might be difficult to organize. CAD (Computed Assisted Diagnosis) is dramatically improving and is able to detect suspicious mammographic lesions, either suspicious microcalcifications, masses or architectural distorsions. CAD mammography might complete or substitute to "human" double reading.

Temporal lobe epilepsy with varying severity: MRI study of 222 patients.

MRI was performed in 222 consecutive adult patients with temporal lobe epilepsy of varying severity from January 1991 to May 1993. The diagnosis of hippocampal sclerosis was established visually by three independent observers. The accuracy of visual assessment of hippocampal asymmetry was compared with volumetric measurements.

[Magnetic resonance imaging of temporal lobe epilepsy].

MR has gained more and more importance in the evaluation of patients with temporal lobe epilepsy (TLE). Until recently, hippocampal sclerosis (which is the most frequent cause of temporal lobe epilepsy, accounting for 50-70% of the cases) could not be identified reliably. Using optimized magnetic resonance imaging techniques, hippocampal sclerosis can now be evidenced in a large proportion of patients with TLE.

[Spinal cord toxoplasmosis and AIDS].

Toxoplasmosis is the most common brain parasitic infection in acquired immunodeficiency syndrome (AIDS). Spinal cord localisations are still rare (2 cases with cerebral involvement, 2 cases without). A case of both spinal cord and cerebral involvement is reported.