Publications by authors named "O Gendelman"
Background: Patients with connective tissue diseases (CTD) can have a wide range of neurological manifestations. Neurological complaints may be the presenting symptom of CTD. Therefore, screening for CTD using anti-nuclear antibodies (ANA) is a common practice.
View Article and Find Full Text PDFRecognizing the need for innovative therapeutic approaches in the management of autoimmune diseases , our current investigation explores the potential of autologous extracellular vesicles (EVs), derived from blood of rheumatoid arthritis (RA) patients, to serve as therapeutic vectors to improve drug delivery. We found that circulating EVs derived from arthritic mice (Collagen-induced arthritis model) express the joint/synovia homing receptor, αVβ3 integrin. Importantly, both autologous labelled EVs, derived from blood of arthritic mice (Collagen antibody-induced arthritis model) and healthy mice-derived EVs, exhibit targeted migration toward inflamed synovia without infiltrating healthy joints, as demonstrated by an in-vivo imaging system.
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- Sarcoidosis is a condition that causes chronic inflammation and the formation of granulomas, which can lead to varying outcomes; some patients have mild issues while others face severe complications and higher mortality risk.
- A retrospective cohort study analyzed data from Clalit Health Services to compare mortality rates between sarcoidosis patients and matched controls, revealing a significantly higher mortality rate (17.7% vs. 10.6%).
- The study found that younger patients (under 50) experienced the highest mortality risk shortly after diagnosis, with age, male gender, and higher comorbidity scores being key predictors of increased mortality.
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- The study aimed to evaluate the risk of seizures in patients with Giant Cell Arteritis (GCA) compared to matched controls in Israel.
- A total of 8,103 GCA patients and 32,412 controls were analyzed, showing that GCA patients had a higher incidence of seizures (15.92 cases per 10,000 person-years) than controls (9.62 per 10,000).
- The findings indicate that GCA patients have a significantly increased risk of seizures, which is likely related to the inflammatory state associated with GCA, rather than pre-existing conditions like stroke.
This paper explores the use of the approximation of isolated resonance method for determining the safe basins (SBs) in the problem of escape from a potential well. This study introduces a novel approach to capture the location and shape of the SBs and establish their erosion profiles. This research highlights the concept of "true" safe basins, which remain invariant with phase shifts, a critical factor often faced in real-world applications.
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