Publications by authors named "O Gefeller"

Thirty years ago, the Global Solar UV Index (UVI) has been introduced as a health promotion instrument to improve sun protection. We assessed systematically global levels of awareness and use of the UVI as a prerequisite for the preventive effectiveness of this public health tool. We conducted a comprehensive literature search across 10 databases, including PubMed, Scopus and Web of Science Core Collection, as well as clinical trial registries and gray literature databases.

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Background: The after-care treatment project KTx360° aimed to reduce graft failure and mortality after kidney transplantation (KTx).

Methods: The study was conducted in the study centers Hannover, Erlangen and Hannoversch Muenden from May 2017 to October 2020 under the trial registration ISRCTN29416382. The program provided a multimodal aftercare program including specialized case management, telemedicine support, psychological and exercise assessments, and interventions.

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Cutaneous melanoma (CM) is a candidate for screening programs because its prognosis is excellent when diagnosed at an early disease stage. Targeted screening of those at high risk for developing CM, a cost-effective alternative to population-wide screening, requires valid procedures to identify the high-risk group. Self-assessment of the number of nevi has been suggested as a component of such procedures, but its validity has not yet been established.

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Article Synopsis
  • The study examined how two-dose COVID-19 vaccinations impact symptoms and immune response in individuals infected with SARS-CoV-2 variants of concern (VOC) like Alpha and Delta, focusing on breakthrough infections (BTIs).
  • It included 300 participants (212 with BTIs, 88 without) from Bavaria, Germany, who were assessed weekly for symptoms, viral load, and antibody response following their infections.
  • Results showed that vaccinated individuals experienced significantly fewer symptoms and had a stronger immune response compared to unvaccinated individuals, supporting the idea that full vaccination can mitigate the severity of infections caused by emerging virus variants.
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SARS-CoV-2 antibody quantity and quality are key markers of humoral immunity. However, there is substantial uncertainty about their durability. We investigated levels and temporal change of SARS-CoV-2 antibody quantity and quality.

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