Publications by authors named "O Garcia-Sanchez"
B-cell regeneration during therapy has been considered as a strong prognostic factor in multiple myeloma (MM). However, the effects of therapy and hemodilution in bone marrow (BM) B-cell recovery have not been systematically evaluated during follow-up. MM (n = 177) and adult (≥50y) healthy donor (HD; n = 14) BM samples were studied by next-generation flow (NGF) to simultaneously assess measurable residual disease (MRD) and residual normal B-cell populations.
View Article and Find Full Text PDFChanges in Muscle Tone, Function, and Pain in the Chronic Hemiparetic Shoulder after Dry Needling Within or Outside Trigger Points in Stroke Patients: A Crossover Randomized Clinical Trial.
Pain Med
November 2020
Article Synopsis
- - The study aimed to evaluate the impact of dry needling on shoulder pain and function in stroke patients, comparing its effects in trigger point (TrP) areas versus non-TrP areas, and checking if improvements persisted after six weeks post-treatment.
- - Nineteen patients participated in a double-blinded trial, receiving both types of dry needling treatments in random order, with various assessments conducted to measure muscle tone, pain intensity, and upper extremity function over six weeks.
- - Results indicated that while dry needling didn't significantly alter muscle tone or function, it did result in greater pain relief for those treated at TrP sites, and these benefits were maintained for six weeks afterward.
Here, we investigated for the first time the frequency and number of circulating tumor plasma cells (CTPC) in peripheral blood (PB) of newly diagnosed patients with localized and systemic plasma cell neoplasms (PCN) using next-generation flow cytometry (NGF) and correlated our findings with the distinct diagnostic and prognostic categories of the disease. Overall, 508 samples from 264 newly diagnosed PCN patients, were studied. CTPC were detected in PB of all active multiple myeloma (MM; 100%), and smoldering MM (SMM) patients (100%), and in more than half (59%) monoclonal gammopathy of undetermined significance (MGUS) cases (p <0.
View Article and Find Full Text PDFFlow cytometry has become a highly valuable method to monitor minimal residual disease (MRD) and evaluate the depth of complete response (CR) in bone marrow (BM) of multiple myeloma (MM) after therapy. However, current flow-MRD has lower sensitivity than molecular methods and lacks standardization. Here we report on a novel next generation flow (NGF) approach for highly sensitive and standardized MRD detection in MM.
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