Synthesis, structures and Hirshfeld surface analyses of 2-hy-droxy-'-methyl-acetohydrazide and 2-hy-droxy--methyl-acetohydrazide.

The structures of the title compounds 2-hy-droxy-'-methyl-acetohydrazide, , and 2-hy-droxy--methyl-acetohydrazide, , both CHNO, as regioisomers differ in the position of the methyl group relative to the N atoms in 2-hy-droxy-acetohydrazide. In the structure of , the 2-hy-droxy-acetohydrazide core [OH-C-C(=O)-NH-NH] is almost planar and the methyl group is rotated relative to this plane. As opposed to , in the structure of all non-hydrogen atoms lie in the same plane.

Synthesis, crystal structure and Hirshfeld surface analysis of a new copper(II) complex based on diethyl 2,2'-(4-1,2,4-triazole-3,5-di-yl)di-acetate.

The title compound, bis-[μ-2,2'-(4-1,2,4-triazole-3,5-di-yl)di-acetato]-bis-[di-aqua-copper(II)] dihydrate, [Cu(CHNO)(HO)]·2HO, is a dinuclear octa-hedral Cu triazole-based complex. The central copper atoms are hexa-coordinated by two nitro-gen atoms in the equatorial positions, two equatorial oxygen atoms of two carboxyl-ate substituents in position 3 and 5 of the 1,2,4-triazole ring, and two axial oxygen atoms of two water mol-ecules. Two additional solvent water mol-ecules are linked to the title mol-ecule by O-H⋯N and O⋯H-O hydrogen bonds.

Modifying Membranotropic Action of Antimicrobial Peptide Gramicidin S by Star-like Polyacrylamide and Lipid Composition of Nanocontainers.

Gramicidin S (GS), one of the first discovered antimicrobial peptides, still shows strong antibiotic activity after decades of clinical use, with no evidence of resistance. The relatively high hemolytic activity and narrow therapeutic window of GS limit its use in topical applications. Encapsulation and targeted delivery may be the way to develop the internal administration of this drug.

Biopharmaceutical studies of a novel sedative sublingual lozenge based on glycine and tryptophan: A rationale for mucoadhesive agent selection.

Effective sedative drugs are in great demand due to increasing incidence of nervous disorders. The present work was aimed to develop a novel sublingual sedative drug based on glycine and L-tryptophan amino acids. Carbopol and different hydroxypropyl methylcellulose species were alternatively tested as mucoadhesive agents intended to prolong tryptophan sublingual release time.

Crystal structure of -poly[[methanoldioxidouranium(VI)]-μ-2-[5-(2-oxidophen-yl)-1-1,2,4-triazol-3-yl]acetato-κ :'].

In the title complex, [U(CHNO)O(CHOH)] , the U cation has a typical penta-gonal-bipyramidal environment with the equatorial plane defined by one N and two O atoms of one doubly deprotonated 2-[5-(2-hy-droxy-phen-yl)-1-1,2,4-triazol-3-yl]acetic acid ligand, a carboxyl-ate O atom of the symmetry-related ligand and the O atom of the methanol mol-ecule [U-N/O 2.256 (4)-2.504 (5) Å].