Publications by authors named "O G Ruiz"
ATP-dependent chromatin remodeling protein ATRX is an essential regulator involved in maintenance of DNA structure and chromatin state and regulation of gene expression during development. ATRX was originally identified as the monogenic cause of X-linked α-thalassemia mental retardation (ATR-X) syndrome. Affected individuals display a variety of developmental abnormalities and skeletal deformities.
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- Leptosphaeria maculans causes blackleg disease in Brassica napus, leading to significant yield losses, with the toxin Sirodesmin PL playing a key role in this process.
- The study focuses on how Sirodesmin PL affects gene expression, plant defenses, and cellular structures in B. napus cotyledons, showing that it upregulates defense-related genes while downregulating photosynthesis-related genes.
- The results indicate that Sirodesmin PL not only triggers defense mechanisms like reactive oxygen species production but also induces cell death through damage to the photosystem II, suggesting its role as a virulence factor for effective infection during the fungus's necrotrophic stage.
Molecular efflux is a mechanism through which bacteria actively expel undesirable substances. This is a crucial line of defense against toxic chemicals in harsh environments. Understanding how efflux works is critical for designing antimicrobial strategies.
View Article and Find Full Text PDFHere we present the Multisite Assembly of Gateway Induced Clones (MAGIC) system, which harnesses site-specific recombination-based cloning via Gateway technology for rapid, modular assembly of between 1 and 3 "Entry" vector components, all into a fourth, standard high copy "Destination" plasmid backbone. The MAGIC toolkit spans a range of in vitro and in vivo uses, from directing tunable gene expression, to driving simultaneous expression of microRNAs and fluorescent reporters, to enabling site-specific recombinase-dependent gene expression. All MAGIC system components are directly compatible with existing multisite gateway Tol2 systems currently used in zebrafish, as well as existing eukaryotic cell culture expression Destination plasmids, and available mammalian lentiviral and adenoviral Destination vectors, allowing rapid cross-species experimentation.
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- Maternal and child malnutrition is a significant public health issue in Mexico, and primary care plays a critical role in ensuring timely medical services and disease detection for women and children under five.
- A study evaluated the quality of nutritional care across various life stages in six Mexican states, using a Quality Index that considers 16 specific indicators to measure compliance levels.
- The findings revealed a concerningly low quality of care, with overall compliance at only 8.3%, primarily due to barriers like insufficient training for health professionals, shortages of resources, and specific program cutbacks.