Publications by authors named "O G Pena"
Article Synopsis
- Researchers studied the TCRβ and TCRα chain sequences in different thymocyte populations from mouse fetuses and young adults to understand how life-stage affects TCR gene usage.
- They found that the foetal thymocyte populations showed a preference for particular gene segments, exhibiting less diversity and more clonotypic expansions compared to adults, indicating distinct developmental characteristics.
- Interestingly, when young adult thymocytes were treated to synchronize differentiation, they displayed more foetal-like gene usage patterns, suggesting that developmental influences can be manipulated.
Article Synopsis
- Drug-induced neuropsychiatric symptoms, like delirium and hallucinations, are common, especially in patients with multiple health issues and taking many medications.
- Sacubitril/valsartan is a heart failure drug that helps reduce hospitalizations, particularly in patients with preserved ejection fraction (HFpEF).
- A case report details a 79-year-old male with HFpEF and end-stage kidney disease who experienced visual hallucinations after beginning treatment with sacubitril/valsartan.
Ablation of Primary and Recurrent Thyroid Cancer: Current and Future Perspectives.
Semin Intervent Radiol
April 2024
Thyroid cancer is the most common endocrine malignancy, and its incidence is increasing, driven in part by the advent of ultrasound, and subsequent increased detection of small, early thyroid cancers. Yet even for small tumors, thyroidectomy with lymph node dissection remains standard of care. Specific to well-differentiated thyroid cancer, surgery has come under scrutiny as a possible overtreatment, in light of stable and favorable survival rates even as guidelines have allowed fewer radical resections and lymph node dissections over time.
View Article and Find Full Text PDFA new series of [FeLn]O nanoparticles, with Ln = Gd; Dy; Lu and = 0.05; 0.1; 0.
View Article and Find Full Text PDFTime Course of Mechanical Ventilation Driving Pressure Levels in Pediatric Acute Respiratory Distress Syndrome: Outcomes in a Prospective, Multicenter Cohort Study From Colombia, 2018-2022.
Jaime Fernández-Sarmiento Ana María Bejarano-Quintero Jose Daniel Tibaduiza Karen Moreno-Medina Rosalba Pardo
Pediatr Crit Care Med
September 2024
Article Synopsis
- High driving pressure (DP) during mechanical ventilation can negatively impact outcomes in pediatric patients with acute respiratory distress syndrome (PARDS), particularly regarding 28-day mortality rates.
- A study of 184 intubated children showed that those with a DP greater than 15 cm H2O at 72 hours had a higher risk for mortality and longer ventilation duration.
- Key findings included that lower tidal volumes were linked to decreased mortality risk, while higher plateau pressures in non-survivors highlighted the importance of managing ventilation parameters effectively.*