[Imbalance in the proteinase-inhibitor system in obstetric sepsis and septic shock].

The condition of proteinase-inhibitor balance was studied in blood plasma of patients with obstetric sepsis. Hypoproteinemia (due to a massive blood loss and toxic effect) was shown to result in a 2-5-fold decrease of the activity of endogenous proteinases in blood plasma versus the control group. The activity of alpha-macroglobulins was also by 2 times lower versus the controls, while the activity of alpha 1-antichymotrypsin and of an acid-stable inhibitor of trypsin was found to be higher by 20-30%.

[Processes of modification of lipoproteins. Physiological and pathogenetical role of modified lipoproteins].

The review is devoted to modification of lipoproteins (Lp) connected with various biological processes. Possible mechanisms of Lp oxidation and the nature of oxidants involved in to these processes are considered. Specific attention is paid to the participation of proteolytic enzymes in modification of Lp.

[Extracorporeal circulation methods in the treatment of nonspecific aortic arteritis].

Aim: Development of a protocol of multiple-modality treatment of patients with nonspecific aortoarteritis (NAA) making use of plasmapheresis and specific plasma adsorption of proteinases.

Materials And Methods: Six patients with NAA aged 15 to 58 years were examined using ultrasonic dopplerography, magnetic imaging, and angiography of the large vessels. Red cell sedimentation rate was assessed, cathepsin G activity, antitryptic activity, and content of C-reactive protein in the blood measured.

[The biochemical and clinical aspects of the participation of granulocytes and their proteinases in a vascular wall lesion].

Some components of plasma and granulocyte proteolytic system, granulocyte activation degree were evaluated in 15 patients with nonspecific aortic arteritis (NAA) and 12 hereditary hypercholesterolemia (HHC) patients. Catepsin G activity in blood plasma of NAA and HHC patients was higher than in donors 8-9 and 6-fold, respectively (p < 0.001).