[Studying the development of imipramine tolerance and prospects of its overcoming with the aid of tianeptine].

Reaction of two groups of mice to sub-chronic imipramine administration has been studied in a series of experiments, where one (control) group received physiological saline instead of imipramine. Then, both groups were randomly divided to receive either tianeptine (two groups) or physiological saline (two groups) for three days. After this period, the reaction of mice to imipramine was assessed again by measuring the immobilization duration in the tail suspension test.

[Experimental study of the effects of citalopram, olanzapine, and their combinations in tests for antipsychotic, antidepressant and anxiolytic activities of drugs].

The effects of citalopram, olanzapine and their combinations were studied in tests on outbred SHR male mice. The locomotor activity was determined in the open field, the antidepressant effects - in the tail suspension test, the anxiety-like behavior- in the light-dark transition test; in addition, the antidopaminergic effects of drugs and their combination were evaluated using the apomorphine-induced stereotypy. The results indicate that olanzapine inhibits locomotor activity in all behavioral tests, whereas citalopram alone has no significant effect and does not modify the action of olanzapine.

Changes in anxiety levels are followed by changes in behavioral strategy in mice subjected to stress and in the extent of stress-induced analgesia.

The experiments reported here demonstrated that corasol increased the extent of analgesia induced by stress and decreased the duration of immobility in mice in a forced swimming test in cold water. Administration of diazepam led to the opposite changes and counteracted the actions of the anxiogen. The effects of the anxiolytic were more apparent in NMRI than mongrel mice, while in mongrel mice the effects of the anxiogen were more marked.

[Is stress-induced analgesia a measure of stress severity?].

When comparing magnitudes of "behavioural despair" (duration of immobility) and stress-induced analgesia in the tail suspension test and cold water swim test with SHR and NMRI male mice. The results might depend on saline injection prior the test and on the fact that exposure to cold water in swim test was sufficient to alter the response patterns. The findings show that the main parameters are closely related to each other.

[A change in the alarm level entails a change in behavioural strategy of mice in stress and a change in analgesia induced by it].

The effects of anxiogenic (pentylentetrazole) and anxiolytic (diazepam) agents on <> and cold swim stress-induced analgesia were investigated in SHR and NMRI male mice. It was shown that behavioral response to acute stress was associated with a change in the pain tolerance threshold. Diazepam increased immobility time and attenuated stress-induced analgesia (SIA).