Biospecific haemosorbents based on proteinase inhibitor. III. Biospecific antiproteinase haemosorbent 'Ovosorb' in complex therapy of acute destructive pancreatitis.

Analysis was carried out of the results of complex therapy in 32 patients with acute destructive pancreatitis for which haemosorbtion on Ovosorb, a biospecific antiproteinase haemosorbent containing an immobilized ovomucoid, was used. The clinical efficiency of haemosorbtion was displayed as a decrease in gravity of endogenous intoxication and related functional and metabolic disturbances, as well as in a reduction of lethality from 24.7% to 6.

[The use of a biospecific antiproteinase hemosorbent in the combined treatment of acute destructive pancreatitis].

Results of treatment of 32 patients with acute destructive pancreatitis are presented. Hemosorption on biospecific antiproteinase hemosorbent "OVOSORB" possessing the property of extraction of the excess of serine proteinases from blood plasma was used. High efficiency of the sorbent for treatment of destructive pancreatitis was shown.

[Treatment of diffuse purulent appendicular peritonitis with antiprotease sorbent "ovosorb"].

The authors studied the character of the therapeutic action of some links of protein metabolism in connection with the use of hemosorption with a biospecific antiprotease hemosorbent "ovosorb" in the complex treatment of 24 patients with diffuse purulent peritonitis of appendicular genesis. It was found that the antiprotease biospecific hemosorbent is marked by high efficacy in the correction of protein metabolism and the consequent systemic disorders in patients with peritonitis of an appendicular genesis. It is shown that "ovosorb" removes selectively from hemocirculation active forms of proteinase of their complexes with inhibitors and, in contrast to carbon sorbents does not possess unspecific sorption of the inhibitors of proteinases and other blood plasms proteins.