[Effect of partial pressure of solute oxygen on the intensity of respiration of cultures of antibiotic producers].

It was shown possible to use feeding of hydrogen peroxide as a method for investigating the impact of dissolved oxygen concentrations on growth and development of microorganisms. The influence of pO2 on the respiration intensity was studied in penicillin- and erythromycin-producing cultures and it was found that dependence of the respiration intensity on pO2 had the form of a curve with saturation, at pO2 equal to zero the value of the culture respiration intensity being different from zero. A mathematical model accounting for the presence in the fermentation broth of microbial agglomerates with the average size depending on the agitation conditions is proposed for describing the relationships.

[Experimental study of vibration agitation in antibiotic biosynthetic processes in laboratory apparatus].

The use of vibroagitation in biosynthesis of antibiotics was shown to be in principle possible. The results of the experiments in 3-liter apparatus equipped with devices for vibroagitation and turbine mixers are presented.