Publications by authors named "O G Aguilar"
Article Synopsis
- Alcohol use disorder (AUD) is linked to binge drinking and can cause lasting changes in the brain's neurocircuitry, particularly in the extended amygdala, leading to neuroinflammation and potential relapse.
- A study using the Drinking in the Dark (DID) model in rodents found that the anti-inflammatory drug minocycline reduced binge drinking behavior without significantly affecting long-term consumption of natural rewards like food and water.
- The research also highlighted significant changes in microglia morphology in the central amygdala but not in the basolateral amygdala, indicating that targeting neuroinflammation could be a promising approach for treating AUD.
The common bean (Phaseolus vulgaris L.) is a crucial legume crop and an ideal evolutionary model to study adaptive diversity in wild and domesticated populations. Here, we present a common bean pan-genome based on five high-quality genomes and whole-genome reads representing 339 genotypes.
View Article and Find Full Text PDFNK cells express activating receptors that signal through ITAM-bearing adapter proteins. The phosphorylation of each ITAM creates binding sites for SYK and ZAP70 protein tyrosine kinases to propagate downstream signaling including the induction of influx. While all immature and mature human NK cells co-express SYK and ZAP70, clonally driven memory or adaptive NK cells can methylate genes and signaling is mediated exclusively using ZAP70.
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