Publications by authors named "O Fondard"
Article Synopsis
- The study looked at how breast cancer radiotherapy affects the heart, specifically how it can lead to problems with the heart's pumping ability, measured by something called global longitudinal strain (LS).
- Researchers found that LS decreased in different layers of the heart muscle six months after treatment, meaning the heart may not work as well over time.
- The biggest changes were in the inner layer of the heart (endocardial layer) and in areas that received the most radiation, suggesting targeted areas of the heart are more affected by the treatment.
Aims: The aim was to assess the effect of a telemonitoring programme vs. standard care (SC) in preventing all-cause deaths or unplanned hospitalisations in heart failure (HF) at 18 months.
Methods And Results: OSICAT was a randomised, multicentre, open-label French study in 937 patients hospitalised for acute HF ≤12 months before inclusion.
Background: Breast cancer (BC) radiotherapy (RT) can induce cardiotoxicity, with adverse events often observed many years after BC RT. Subclinical left ventricular (LV) dysfunction can be detected early after BC RT with global longitudinal strain (GLS) measurement based on 2D speckle-tracking echocardiography. This 6-month follow-up analysis from the BACCARAT prospective study aimed to investigate the association between cardiac radiation doses and subclinical LV dysfunction based on GLS reduction.
View Article and Find Full Text PDFBackground: Radiotherapy (RT) for breast cancer presents a benefit in terms of reducing local recurrence and deaths resulting from breast cancer but it can lead to secondary effects due to the presence of neighboring cardiac normal tissues within the irradiation field. Breast RT has been shown to be associated with long-term increased risk of heart failure, coronary artery disease, myocardial infarction and finally cardiovascular death more than 10 years after RT. However, there is still a lack of knowledge for early cardiotoxicity induced by breast RT that can appear long before the onset of clinically significant cardiac events.
View Article and Find Full Text PDFBackground: In asymptomatic mitral stenosis (MS), the usefulness of peak exercise Doppler echocardiography (DE) values is acknowledged, but the role of values recorded during the first stage of DE remains unclear.
Methods: DE was analyzed in 48 asymptomatic patients with significant MS and revealed dyspnea in 22 patients (46%).
Results: MS severity and rest and peak systolic pulmonary artery pressures (SPAPs) were not different between patients who did and did not develop dyspnea.