Publications by authors named "O Faure"
Article Synopsis
- After initial marketing authorization of a pharmaceutical product, manufacturers must manage numerous chemistry, manufacturing, and control (CMC) post-approval changes (PACs), complicated by varying regulatory requirements across countries.
- The World Health Organization (WHO) advocates for a "reliance" approach among national regulatory authorities (NRAs), allowing them to trust evaluations from efficient authorities to speed up the review process for PACs.
- Sanofi, with support from organizations like Health Canada and WHO, has launched a pilot program involving 21 NRAs to implement these reliance principles, aiming to shorten approval timelines for a vaccine's CMC PACs to six months after initial approval.
Agricultural soils can contain high arsenic (As) concentrations due to specific geological contexts or pollution. Fertilizer amendments could influence As speciation and mobility thus increasing its transfer to crops and its toxicity. In the present study, field-relevant amounts of fertilizers were applied to soils from a cultivated field that was a former ammunition-burning site.
View Article and Find Full Text PDFBecause of their high content in toxic metals, steel slag dumps are potential threats for the environment and public health. Among management methods that could mitigate their hazard, aided-phytostabilization is a relevant, though challenging, option. Indeed, steel slags are very unfavorable for plant growth, due to metal toxicity and very alkaline pH (>10).
View Article and Find Full Text PDFMost former industrial sites are contaminated by mixtures of trace elements and organic pollutants. Levels of pollutants do not provide information regarding their biological impact, bioavailability and possible interactions between substances. There is genuine interest in combining chemical analyses with biological investigations.
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