Publications by authors named "O Facy"
Background: The use of multiagent FOLFIRINOX chemotherapy for pancreatic adenocarcinoma in a neoadjuvant setting has been associated with an increased rate of complete pathological response (CPR) after surgery. This study investigated the long-term outcomes of patients with CPR in a multicenter setting to identify prognostic factors for overall survival (OS) and recurrence-free survival (RFS).
Methods: This retrospective cohort study examined biopsy-proven pancreatic adenocarcinomas with CPR after neoadjuvant chemotherapy or chemoradiotherapy and surgery, between January 2006 and December 2023 across 22 French and 2 Belgian centers.
Article Synopsis
- - The study aims to assess how effective drain fluid lipase is in predicting postoperative pancreatic fistula, a serious complication after pancreatic surgery, and determines the most suitable day for measuring this biomarker.
- - Conducted across seven hospitals, the LIPAse DRAIN study analyzed drain fluid from 625 patients over six days, finding that drain fluid lipase is a reliable indicator on days 3 and 4, with significant statistical values suggesting its diagnostic utility.
- - Results showed that on postoperative day 3, a specific threshold of lipase levels could reasonably identify patients at risk for developing a pancreatic fistula, recommending routine measurement of this biomarker by day 3 post-surgery.
Study Objective: To evaluate the feasibility and benefit of a diagnostic and therapeutic algorithm for management of patients presenting with a high C-reactive protein (CRP) level after colorectal surgery.
Patients And Methods: Prospective study including patients with CRP>125mg/L at the 4th postoperative day following elective colorectal surgery. The protocol involved CT-scan of which the results were to orient subsequent management: antibiotics, radiological drainage, endoscopy or surgical redo.
Article Synopsis
- Minimally invasive surgery (MIS) for left pancreatic resections has been increasingly utilized, but its advantages over traditional open surgery for distal pancreatectomy in treating pancreatic neuroendocrine tumors are still debated.
- A retrospective study involving 274 patients across 21 French centers analyzed short and long-term outcomes of MIS versus open surgery, focusing on factors like tumor size and patient characteristics.
- Results showed that MIS reduced major complications and delayed gastric emptying while maintaining comparable survival rates, suggesting it is a safe option for patients with resectable left pancreatic neuroendocrine tumors.