Specific oxylipins enhance vertebrate hematopoiesis via the receptor GPR132.

Epoxyeicosatrienoic acids (EETs) are lipid-derived signaling molecules with cardioprotective and vasodilatory actions. We recently showed that 11,12-EET enhances hematopoietic induction and engraftment in mice and zebrafish. EETs are known to signal via G protein-coupled receptors, with evidence supporting the existence of a specific high-affinity receptor.

Assessment of the nucleolar organizer regions by automated image analysis in benign and malignant colonic tumours and adjacent tissues in rats.

An automated computer image analysis technique was used to study the morphological parameters of argyrophilic nucleolar organizer regions (AgNORs) in chemically induced rat colonic tumours of different grades. Different nuclear parameters were of different diagnostic value. For distinguishing tumorous tissue from normal tissue all the parameters studied were capable of serving as diagnostic markers.

Direct contact superpolishing of sapphire.

We show that sapphire can be superpolished in direct contact with a tin lap by using colloidal silica in water as the polishing liquid. The residual roughness is <0.05 nm rms.

Antagonism of diazepam by aminophylline in healthy volunteers.

Six healthy volunteers participated in a randomized, double-blind cross-over study of the effects of intravenous aminophylline on diazepam-induced sedation. Each subject participated in two phases and in each phase received either diazepam (15 mg intravenously) followed by placebo or diazepam followed by aminophylline (2 mg/kg intravenously). Critical flicker fusion times and reaction times were measured sequentially as indices of vigilance.

Oxprenolol plus ethanol causes no central nervous system depression--a comparison with lorazepam plus ethanol.

Oxprenolol, a fat-soluble beta-adrenergic blocker, promoted as an anxiolytic agent to alleviate peripheral symptoms associated with anxiety, and lorazepam, a 1,4-benzodiazepine anxiolytic drug, may both depress central nervous system (CNS) function. It is generally accepted that ethanol, when concurrently ingested, potentiates the CNS-depressant effects of drugs. The effects on CNS function of oxprenolol, lorazepam and placebo alone and in combination with ethanol were determined by a Leeds Psychomotor Tester and we concluded that oxprenolol in combination with ethanol is less hazardous to people operating power tools/machines or driving motor vehicles than the combination of lorazepam with ethanol.