Publications by authors named "O F Shangina"
International differences in the incidence of many cancer types indicate the existence of carcinogen exposures that have not yet been identified by conventional epidemiology make a substantial contribution to cancer burden. In clear cell renal cell carcinoma, obesity, hypertension and tobacco smoking are risk factors, but they do not explain the geographical variation in its incidence. Underlying causes can be inferred by sequencing the genomes of cancers from populations with different incidence rates and detecting differences in patterns of somatic mutations.
View Article and Find Full Text PDFPurpose: To investigate whether postdiagnosis smoking cessation may affect the risk of death and disease progression in patients with renal cell carcinoma (RCC) who smoked at the time of diagnosis.
Methods: Two hundred twelve patients with primary RCC were recruited between 2007 and 2016 from the Urological Department in N.N.
Article Synopsis
- A study investigated the role of tumor genomics in predicting recurrence risk for patients with localized clear-cell renal cell carcinoma (ccRCC) after surgery, using a large cohort of 943 cases.
- Researchers analyzed the mutation status of 12 genes, particularly focusing on von-Hippel Lindau (VHL) mutations, finding distinct groups with different disease-free survival rates.
- The results suggest that genomic profiling can help tailor adjuvant treatment decisions, with patients having only a VHL mutation possibly needing less aggressive therapy compared to those with additional mutations.
Article Synopsis
- The study analyzed data from the INHANCE consortium to compare the effects of cigarette smoking and alcohol consumption on head and neck cancer risk in less developed and more developed countries.
- It found that the risk profiles associated with smoking and alcohol use vary between these country types, with specific cancers showing different patterns of risk.
- The research highlights how factors like industrialization and economic development influence the relationship between lifestyle habits (smoking and drinking) and head and neck cancer incidence.
Background: Lung cancer is the leading cause of cancer death worldwide, and about one half of patients with lung cancer are active smokers at diagnosis.
Objective: To determine whether quitting smoking after diagnosis of lung cancer affects the risk for disease progression and mortality.
Design: Prospective study of patients with non-small cell lung cancer (NSCLC) who were recruited between 2007 and 2016 and followed annually through 2020.