[Effect of phospholipids containing omega-3 fatty acids on structural changes of microsomal lipids in cell membranes of functionally different cells].

As a result of the experimental researches conducted it has been shown that administration of some normal animal marine phospholipids (PL) including in their structure omega-3 polyunsaturated fatty acids (PUFA) provides for quantitative changes of individual PL, fatty acids (FA) content and quantity in general and individual PL of liver, heart, brain and gonads microsomes. While estimating general microsomal PL fraction FA content under the action of PL omega-3 PUFA FA concentration change, unsaturation index (omega 6/omega 3) and relation of arachidonic acid to docosahexenic (AA/DHA) decrease have been identified. The decrease of AA/DHA relationship occurs due to AA and DHA quantitative changes.

[Helicobacter pylori prevalence among patients with gastroduodenal diseases in Kiev].

It is for the first time in Ukraine that a study has been made on the epidemiology of H. pylori infection among patients with disorders of the stomach and duodenum. The diagnosis of the infection was done with the aid of various invasive and noninvasive tests, 13C-urea breathing test, a unique for Ukraine and countries of the Western Europe method of examination included.

[Interaction of neuroblastoma C 1300 N18 cells with liposomes and intermembrane metabolism of lipids].

The methods of isotopic and fluorescent labels have shown that interaction of cells of neuroblastoma S 1300 N 18 with small one-layer neutral liposomes prepared of the egg phosphatidyl choline with the addition of different amounts of cholesterol is realized by two mechanisms: the transmembrane transfer of cholesterol by the concentration gradient and membrane lipid metabolism proper, the ratios of cholesterol phospholipids in the biological and artificial membranes being equal. A dependence is established of the neuroblastoma cell viability on the activity of the cholesterol membrane metabolism. A problem on the mechanism which causes the death of cells during the interaction with phosphatidyl-cholesterol liposomes is under discussion.

[Effect of histamine and insulin on the sterol composition of gastric secretions in dogs].

The effect of gastric secretion activators with a different mode of action was studied on the qualitative and quantitative composition of sterol in dog gastric juice. Cholesterol was established to be the basic component of the unsaponifiable fraction of both histamine- and insulin-stimulated gastric juice. The presence of unsaponifiable substances and cholesterol was much higher in the histamine-stimulated gastric juice.

[Squalene and sterols of rat stomach tissue and the effect of acetylsalicylic acid on their content].

The contents of squalene, free and esterified sterols (metastenol, lathosterol, 7-dehydrocholesterol, cholesterol) in tissues of the rat esophageal and glandular stomach were studied in normalcy and under the effect of acetyl salicylic acid. The tissue of different stomach regions differs in the content of squalene, free and esterified sterols. Under the effect of acetyl salicylic acid the content of squalene and free sterols in tissues of the both stomach regions lowers.