Publications by authors named "O F Moroz"

α-Amylases are the workhorse enzymes of starch degradation. They are central to human health, including as targets for anti-diabetic compounds, but are also the key enzymes in the industrial processing of starch for biofuels, corn syrups, brewing and detergents. Dissection of the activity, specificity and stability of α-amylases is crucial to understanding their biology and allowing their exploitation.

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Article Synopsis
  • - Cartilage endplate cell (CEPC) and nucleus pulposus cell (NPC) inflammation play a crucial role in intervertebral disc degeneration (IVDD), with iron ions and reactive oxygen species (ROS) being significant contributors to this process.
  • - A new composite gel, CAP-sEXOs@Gel, has been developed, which uses engineered exosomes loaded with salvianolic acid A to target CEPCs and release them slowly, while also neutralizing the acidic environment to alleviate NPC inflammation.
  • - The CAP-sEXOs@Gel effectively reduces intracellular iron and ROS levels, helping maintain mitochondrial function in CEPCs and suppressing inflammatory pathways, indicating its potential as a therapeutic strategy for reversing IVDD.
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Aim: Non-communicable diseases (NCDs) in elderly are a significant problem in Ukraine. It is expected that the ongoing war will augment this problem. The study aimed to analyze the trends of disability due to NCDs s in newly-diagnosed elderly patients between 2013 and 2023.

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Millions of people worldwide are affected by neurodegenerative diseases and cognitive impairment, which includes dementia, while there are only symptomatic treatments available for this syndrome at present. However, several important prospective drug targets have been identified in recent years that can potentially arrest or even reverse the progression of neurodegenerative diseases. Their natural or synthetic ligands are currently in the experimental stage of drug development.

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Correct elaboration of N-linked glycans in the secretory pathway of human cells is essential in physiology. Early N-glycan biosynthesis follows an assembly line principle before undergoing crucial elaboration points that feature the sequential incorporation of the sugar -acetylglucosamine (GlcNAc). The activity of GlcNAc transferase V (MGAT5) primes the biosynthesis of an N-glycan antenna that is heavily upregulated in cancer.

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