Publications by authors named "O F Gavrilova"
Rigidified nucleoside derivatives with (N)-methanocarba replacement of ribose have been repurposed as peripheral subtype-selective 5-HT serotonin receptor antagonists for heart and lung fibrosis and intestinal/vascular conditions. 4'-Cyano derivative (MRS8209; , 4.27 nM) was 47-fold (human binding, but not rat and mouse) and 724-fold (functionally) selective at 5-HTR, compared to antitarget 5-HTR, and predicted to form a stable receptor complex using docking and molecular dynamics.
View Article and Find Full Text PDFFollowing a meal, glucagon-like peptide 1 (GLP1) and glucose-dependent insulinotropic polypeptide (GIP), the 2 major incretins promoting insulin release, are secreted from specialized enteroendocrine cells (L and K cells, respectively). Although GIP is the dominant incretin in humans, the detailed molecular mechanisms governing its release remain to be explored. GIP secretion is regulated by the activity of G protein-coupled receptors (GPCRs) expressed by K cells.
View Article and Find Full Text PDFArticle Synopsis
- The study highlights that in mice, nearly 40% of the light phase and 80% of the dark phase are marked by periods of increased energy expenditure (EE), known as ultradian bouts.
- These bouts are associated with higher body temperatures and consist of most physical activity and wakefulness, suggesting that they are more indicative of mouse physiology than the traditional light/dark cycles.
- The findings indicate that these ultradian bouts, resulting from brain-driven increases in body temperature, lead to significant energy expenditure from various bodily activities, making mouse metabolic physiology largely episodic rather than solely reliant on circadian rhythms.
Dry rot of potato tubers is a harmful disease caused by species of the genus. Studies on the composition and features of spp. that cause the disease in Russia are limited.
View Article and Find Full Text PDFA distinct adipose tissue distribution pattern was observed in patients with methylmalonyl-CoA mutase deficiency, an inborn error of branched-chain amino acid (BCAA) metabolism, characterized by centripetal obesity with proximal upper and lower extremity fat deposition and paucity of visceral fat, that resembles familial multiple lipomatosis syndrome. To explore brown and white fat physiology in methylmalonic acidemia (MMA), body composition, adipokines, and inflammatory markers were assessed in 46 patients with MMA and 99 matched controls. Fibroblast growth factor 21 levels were associated with acyl-CoA accretion, aberrant methylmalonylation in adipose tissue, and an attenuated inflammatory cytokine profile.
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