[Antitumor action and other regulatory effects of low intensity electromagnetic and chemical factors in experiment].

This paper presents a brief overview of the results of the original researches of biological responses induced by agents of cytostatic and regulatory actions in small doses, as well as weak electromagnetic radiation of different frequency bands. The possibility of obtaining the expressed antitumor, antistress and geroprotective effects has been shown. The question of the relation of system mechanisms of realization of these effects with structural rearrangements in biological fluids, as well as the promising directions for optimizing the therapeutic properties of the informational impacts are discussed.

A method for reproduction of metastases in the liver.

A new method for reproduction of metastatic involvement of the liver in outbred albino rats is proposed. The use of the method rules out the effects of stress factors (surgical intervention, total anesthesia) on malignant tumor metastasizing, making it maximally similar to the natural process. The method allows visual evaluation of the time course of the primary tumor node growth.

Experimental study of structural, functional, and biochemical changes in immune organs under conditions of antitumor activity of copper nanoparticles.

The effects of copper nanoparticles on the structure and function of the immune system organs (thymus and spleen) and intensity of free radical processes in the spleens of rats with sarcoma 45 were studied. A relationship between morphological and biochemical changes and antitumor efficiency of copper nanoparticles was demonstrated.

Morphofuctional aspects of antitumor activity of low-intensity microwave resonance radiation in experiment.

Effects of low-intensity microwave radiation with bioactive frequency were studied in rats with transplanted sarcoma 45. After exposure to microwave radiation in the regimen of activation therapy, the antitumor effect was observed in 50% animals (marked inhibition of tumor growth or its partial regression). Light and electron microscopy revealed destructive changes in the tumor tissue, accumulation of activation of immune system cells, and signs of the increase in tumor cell differentiation.

[Magnetic fields, adaptation reaction and self-organization of live systems].

It is shown that general nonspecific adaptational reactions are the basis for mechanism of magnetic field effects at the organism level. The character of changes in organism and its subsystems (pattern of a general nonspecific adaptational reactions) is determined by the type of the reaction developing under magnetic field: stress or unknown before antistress reactions of training, calm activation and enhanced activation. The protection and damages under stress are interwoven, homeostatic parameters go beyond norm.