Publications by authors named "O F El-Rashidy"
Background: One of the most common long-term neurological disorders affecting children is epilepsy. Even with effective antiseizure medications, one-third of epileptic patients develop drug-resistant epilepsy (DRE). Numerous treatments have been offered to these DRE patients, though with varying degrees of effectiveness.
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- Despite research, many neurodevelopmental disorders remain unexplained; our study focuses on a female patient with specific genetic anomalies and brain abnormalities.
- Genomic analysis revealed a complex chromosomal rearrangement involving chromosomes 5, 18, and additional material from chromosome 2.
- The findings highlight the importance of using various genomic technologies to explore complex genetic disorders and improve understanding of their mechanisms.
Background: Benzodiazepines are the recommended first-line treatment of acute seizures. We wished to compare the efficacy, side effects, and satisfaction after midazolam administration by the buccal, intranasal, or intramuscular route in the treatment of acute seizures in children at homes and in emergency room (ER).
Methods: A prospective, randomized, controlled trial was performed in children aged one month to 17 years with acute seizures lasting longer than five minutes.
Article Synopsis
- A new evidence-based clinical practice guideline (CPG) has been created for the emergency management of seizures in children in Egypt, adapting international recommendations to local healthcare needs.
- The initiative was led by the Egyptian Pediatric Clinical Practice Guidelines Committee in collaboration with 15 universities and aims to standardize seizure treatment with an easy-to-apply protocol.
- The adapted guidelines were based on reviews from various international sources and included multiple implementation strategies to ensure effective use by healthcare professionals and stakeholders in Egypt.
Article Synopsis
- This study examined a female patient with a neurodevelopmental disorder (NDD) and identified complex genetic alterations including a terminal loss on chromosome 5 and a gain on chromosome 18, despite her parents having normal genetic copies of these chromosomes.
- The researchers discovered an unbalanced translocation between chromosomes 5 and 18, with additional genetic material from chromosome 2, indicating a complex chromosomal rearrangement (CCR).
- The findings highlight the necessity of using different genomic technologies to investigate the genetic basis of complicated NDD cases and enhance understanding of genetic disorders.