Inflammatory and oxidative biomarkers of disease severity in dogs with parvoviral enteritis.

Objectives: To study changes in serum C-reactive protein, haptoglobin, ceruloplasmin and albumin concentration, total anti-oxidant capacity and paraoxonase-1 and butyrylcholinesterase activity in dogs with parvoviral enteritis of different degrees of clinical severity.

Methods: Prospective study of 9 healthy and 43 dogs with parvoviral enteritis that were classified into mildly, moderately and affected groups.

Results: Dogs with parvoviral enteritis had a significant increase in C-reactive protein compared with healthy dogs, with an increase of higher magnitude in animals with more severe clinical signs.

Effect of experimental endotoxemia on thrombelastography parameters, secondary and tertiary hemostasis in dogs.

Background: Thrombelastography (TEG) and indicators of secondary and tertiary hemostasis might be altered in dogs with endotoxemia.

Hypothesis: Endotoxemia influences measures of coagulation in dogs.

Animals: Ten healthy cross-bred dogs.

Adiponectin and IGF-1 are negative acute phase proteins in a dog model of acute endotoxaemia.

The objective of this study was to evaluate the influence of an experimentally induced acute inflammation on serum adiponectin and insulin-like growth factor 1 (IGF-1) levels in the dog, and to compare their evolution with other well-established acute phase proteins (APPs) such as C-reactive protein (CRP), and haptoglobin (Hp). Therefore levels of adiponectin, IGF-1 and a profile of APPs were measured in healthy dogs after intravenous administration of E. coli LPS (0.

Tei index (myocardial performance index) and cardiac biomarkers in dogs with parvoviral enteritis.

Tei index (myocardial performance) and cardiac biomarkers were evaluated in dogs with parvoviral enteritis (PVE). Tei index was calculated as isovolumic contraction time plus isovolumic relaxation time divided by ejection time. Myocardial and skeletal muscle damages were assessed by serum levels of cardiac troponin I (cTnI), creatine (phospho) kinase, lactate dehydrogenase and aspartate aminotransferase.

Prognostic value of serum acute-phase proteins in dogs with parvoviral enteritis.

Objective: To evaluate the acute-phase protein response in dogs with parvoviral enteritis as predictor of the clinical outcome.

Methods: Canine parvovirus infection was diagnosed based on the compatible clinical findings and confirmed by the canine parvovirus antigen test in 43 dogs of less than six months of age. Blood samples for complete blood cell count and acute-phase proteins (C-reactive protein, haptoglobin, ceruloplasmin and albumin) were collected before treatment.