Turkish Adaptation of QLQ-SH22 Quality of Sexual Life Assessment Scale in Cancer Patients - Validity and Reliability Study.

Objectives: Cancer or its treatment can have direct or indirect effects on sexual functions. Routine assessment of sexual functioning is essential in cancer patients to identify sexual problems and provide counseling to patients about these issues. This study aimed to investigate the validity and reliability of the Turkish version of the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire - Sexual Health 22 prepared for the assessment of sexual function in cancer patients.

Total Neoadjuvant Therapy Versus Neoadjuvant Chemoradiation for Locally Advanced Rectal Cancer: A Multi-Institutional Real-World Study.

Total neoadjuvant therapy (TNT) has emerged as a promising approach for managing locally advanced rectal cancer (LARC), aiming to enhance resectability, increase pathological complete response (pCR), improve treatment compliance, survival, and sphincter preservation. This study compares the clinical outcomes of TNT, with either induction or consolidation chemotherapy, to those of the standard chemoradiotherapy (CRT). In this retrospective multi-institutional study, patients with stage II-III LARC who underwent CRT or TNT from seven oncology centers between 2021 and 2024 were retrospectively analyzed.

Severity scores, damage indices, and the concept of the colchicine-resistant patient in familial Mediterranean fever.

Familial Mediterranean fever is a common autoinflammatory disease. The primary treatment is colchicine; however, 5-10% of patients do not respond to colchicine and are considered colchicine resistant. Colchicine resistance and disease severity are highly associated, with each used to assess and define the other.

One-Step Electrochemical Sensing of CA-125 Using Onion Oil-Based Novel Organohydrogels as the Matrices.

To reduce the high mortality rates caused by ovarian cancer, creating high-sensitivity, quick, basic, and inexpensive methods for following cancer antigen 125 (CA-125) levels in blood tests is of extraordinary significance. CA-125 is known as the exclusive glycoprotein employed in clinical examinations to monitor and diagnose ovarian cancer and detect its relapses as a tumor marker. Elevated concentrations of this antigen are linked to the occurrence of ovarian cancer.