[Effect of homocysteine on left ventricular structural and functional parameters in patients on programmed hemodialysis].

Aim: To determine the effect of plasma homocysteine (Hc) on the structure and function of the left ventricle (LV) in patients treated by programmed hemodialysis.

Subjects And Methods: 109 patients on programmed hemodialysis were examined. Blood Hc levels were determined and echocardiography was performed in all the patients.

[The diagnostic value of laboratory markers of epithelium damage in patients passing the program hemodialysis].

The sampling of 82 patients was included into the study to assess the diagnostic value of laboratory markers of endothelium dysfunction (homocysteine concentration, von Willebrand factor activity) in patients passing the treatment of program hemodialysis. The study detected the reliable increase of homocysteine level and activity of von Willebrand factor in patients passing hemodialysis. The association of increasing of concentration of homocysteine and von Willebrand factor activity with rate of cardiovascular complications in patients passing the program in patients passing hemodialysis was established.

[Role of endothelium in remodelling a myocardium left ventricular at patients on a hemodialysis].

To study influence of markers of function endothelium on structurally functional indicators left ventricular at patients on a hemodialysis. 98 Patients on a hemodialysis are surveyed. To all patients defined concentration stable metabolites of oxyde nitrogen whey of blood, total cholesterol, cholesterol of low density lipoproteine, cholesterol of high density lipoproteine, triglycerides, homocysteine, Willebrand factor, spent echocardiography research.

[Determinants of vascular wall stiffness in patients with chronic renal disease undergoing hemodialysis].

Examination of 109 patients with chronic renal disease undergoing hemodialysis revealed significant impairment of arterial wall distensibility (accordingly, decreased Peterson's and Young's elastic moduli, distensibility coefficient). The relative thickness of the common carotid artery and pulse wave velocity were significantly greater than in practically healthy subjects. Independent factors influencing arterial wall rigidity included age, arterial pressure, total cholesterol and homocystein, stable metabolites of nitric oxide, creatinine, calcium, phosphorus levels, calcium x phosphorus product, duration of hemodialysis, interdialytic weight gain.