Risk of colorectal neoplasia associated with the adenomatous polyposis coli E1317Q variant.

Background: Reports of the risk of colorectal neoplasia associated with a variant of the adenomatous polyposis coli (APC E1317Q) gene are conflicting. Using a case-control design, we investigated this relationship within a clinic-based cohort followed through the Integrated Cancer Prevention Center and the Tel-Aviv Sourasky Medical Center.

Materials And Methods: All study subjects were tested for the APC E1317Q variant at enrollment.

The APC E1317Q and I1307K polymorphisms in non-colorectal cancers.

Mutation of the adenomatous polyposis coli (APC) gene is an important initiating factor in the early stages of the multi-step colorectal cancer (CRC) carcinogenesis. APC E1317Q and I1307K variants have been linked to CRC. The aim of this study was to examine the association of these variants with non-colorectal cancers.