Transtympanic administration is used clinically for the injection of gentamicin and/or corticosteroids. This atraumatic route is based on passive diffusion through the round window membrane (RWM). The main limitation of this method is related to the clearance through the Eustachian tube, making the concentration of the therapeutic agent at the intracochlear level uncertain and limited.
View Article and Find Full Text PDFThe release of carbon dioxide (CO) into the atmosphere has accelerated during the last two decades. Elevated atmospheric CO concentration (eCO) is known as an agent that improves plant photosynthesis. However, eCO was also correlated with alterations in the macronutrient and micronutrient compositions of various dietary crops.
View Article and Find Full Text PDF(1) Background: The anthropogenically induced rise in atmospheric carbon dioxide (CO) and associated climate change are considered a potential threat to human nutrition. Indeed, an elevated CO concentration was associated with significant alterations in macronutrient and micronutrient content in various dietary crops. (2) Method: In order to explore the impact of elevated CO on the nutritional-health properties of tomato, we used the dwarf tomato variety Micro-Tom plant model.
View Article and Find Full Text PDF: Compare pancreatic ductal adenocarcinoma (PDAC), preclinical models, by their transcriptome and drug response landscapes to evaluate their complementarity. : Three paired PDAC preclinical models-patient-derived xenografts (PDX), xenograft-derived pancreatic organoids (XDPO) and xenograft-derived primary cell cultures (XDPCC)-were derived from 20 patients and analyzed at the transcriptomic and chemosensitivity level. Transcriptomic characterization was performed using the basal-like/classical subtyping and the PDAC molecular gradient (PAMG).
View Article and Find Full Text PDFPatient-derived tumor xenograft (PDX) mouse models have emerged as an important oncology research platform to study tumor evolution, mechanisms of drug response and resistance, and tailoring chemotherapeutic approaches for individual patients. The lack of robust standards for reporting on PDX models has hampered the ability of researchers to find relevant PDX models and associated data. Here we present the PDX models minimal information standard (PDX-MI) for reporting on the generation, quality assurance, and use of PDX models.
View Article and Find Full Text PDF