Publications by authors named "O Dorigo"
Struma ovarii (SO) is a rare subtype of ovarian teratoma composed of more than 50% thyroid tissue. Extraovarian spread of SO, called peritoneal strumosis, was previously considered benign given the lack of histological malignant features. However, the 2020 World Health Organization Classification of Female Genital Tumors reclassified peritoneal strumosis as highly differentiated follicular carcinoma of ovarian origin (HDFCO), highlighting its low-grade malignant potential.
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- The study focused on analyzing trends in the incidence and mortality rates of ovarian, fallopian tube, and primary peritoneal cancers from 2000 to 2019 using the US SEER 17 database.
- Overall, the findings revealed a decline in both incidence and mortality rates for these cancers during the study period, particularly for epithelial cancers.
- The decrease was significant for high-grade and low-grade epithelial cancers, while rates for ovarian stromal and germ cell cancers remained unchanged.
Objective: Aberrant β-catenin distribution has been theorized as a predictive biomarker for recurrence in early stage, low grade endometrioid endometrial cancer.
Methods: This retrospective single-institution cohort study reviewed 410 patients with endometrial cancer from May 2018 to May 2022. Only endometrioid histology was included.
Article Synopsis
- The study investigates the impact of substantial lymphovascular space invasion (LVSI) and abnormal p53 expression (p53abnl) on outcomes for patients with early-stage endometrial cancer who have undergone lymph node assessment.
- It analyzes data from 126 patients, focusing on local, regional, and distant metastasis rates, as well as overall survival (OS), using statistical methods like Kaplan-Meier.
- The findings indicate that patients with either p53abnl or LVSI had significantly poorer outcomes, suggesting that these patients could benefit from more aggressive treatment with external beam radiation therapy (EBRT).
Objectives: Emerging data suggests that abnormal (nuclear) β-catenin expression in some settings is associated with poorer outcomes. Our study aimed to verify the significance of abnormal β-catenin expression in early-stage endometrial cancer patients and determine if adjuvant radiation therapy (RT) improves local control.
Methods: We identified 213 patients with FIGO 2018 stage I-II endometrioid endometrial cancer who underwent surgery from 2009 to 2021 with β-catenin expression assessed.