Publications by authors named "O Detante"
Article Synopsis
- The study investigates the differences between cerebral amyloid angiopathy-related inflammation (CAA-RI) and biopsy-positive primary angiitis of the CNS (BP-PACNS), focusing on their clinical and radiologic presentations as well as relapse rates.
- It included 104 patients with CAA-RI and 52 with BP-PACNS, revealing that CAA-RI tends to show more white matter lesions and hemorrhagic features, while BP-PACNS is associated more with headaches and motor deficits.
- The results indicate significant differences in features between the two conditions, suggesting that they may require different diagnostic approaches and could have varying outcomes in terms of recurrence.
Article Synopsis
- Severe sleep apnea affects about one-third of stroke patients and contributes to increased sleepiness, which worsens recovery outcomes after a stroke.
- In a study of 81 stroke patients, researchers found that while both groups reported similar levels of sleepiness at the start, stroke patients experienced a greater improvement in their sleepiness over time compared to matched individuals without stroke.
- Interestingly, the study concluded that having sleep apnea and using CPAP didn't significantly impact how sleepiness changed post-stroke, suggesting that sleepiness may not be a key indicator of sleep apnea in these patients.
Background: Lateropulsion is a deficit in body orientation with respect to gravity, frequent after stroke. Although it is a primary factor affecting mobility, the impact of its attenuation on balance and gait recovery has never been investigated. Moreover, most studies on the lateropulsion time-course focus on severe forms suspected to have a poor recovery, which is not proven.
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- Stroke is the leading cause of disability, with brain repair mechanisms often failing to ensure complete recovery, affecting various brain cell types and the extracellular matrix crucial for brain plasticity.
- Regenerative medicine, particularly cell therapies, shows promise in reducing post-stroke disability by enhancing neuroprotection and neural repair, though optimal methods and timing for treatment remain topics of debate.
- Current research focuses on different cell types, such as mesenchymal stem cells and neural stem cells, as well as innovative strategies involving growth factors and biomaterials to improve the efficacy of therapies in post-stroke recovery.
Article Synopsis
- The study aimed to determine which clinical and radiological features are linked to positive CNS biopsies in patients suspected of having primary angiitis of the central nervous system (PACNS).
- Out of 200 patients with PACNS, 100 underwent biopsies, with 61% returning positive; factors like being female, having seizures or cognitive impairment, and specific imaging findings were associated with positive results.
- The findings suggest that certain characteristics can aid doctors in deciding whether or not to perform a CNS biopsy for suspected PACNS cases.