Publications by authors named "O De La Calle"
The aim of this cluster-randomised controlled trial was to investigate the training and detraining effects of two different-volume Copenhagen Adduction Exercise (CAE) protocols on adductor squeeze strength. Thirty high-level rink hockey players (14 y.o.
View Article and Find Full Text PDFBackground And Objectives: Immune-mediated necrotizing myopathy (IMNM) caused by antibodies against 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) is an inflammatory myopathy that has been epidemiologically correlated with previous statin exposure. We characterized in detail a series of 11 young statin-naïve patients experiencing a chronic disease course mimicking a limb-girdle muscular dystrophy. With the hypothesis that HMGCR upregulation may increase immunogenicity and trigger the production of autoantibodies, our aim was to expand pathophysiologic knowledge of this distinct phenotype.
View Article and Find Full Text PDFArticle Synopsis
- Defective signaling of the FAS molecule, linked to autoimmune lymphoproliferative syndrome (ALPS), leads to hypergammaglobulinemia and fewer conventional memory B cells due to disrupted B cell differentiation.
- Analysis of ALPS patients revealed low memory B cell numbers, fewer germinal center B cells, and an expanded extrafollicular B cell response, indicating a shift in B cell fate.
- The study proposes that abnormal non-apoptotic FAS signaling affects the mTOR pathway and gene expression, contributing to the altered B cell responses observed in ALPS.
Clinical Scenario: Injuries that affect the groin region are among the most common in football players. To prevent this condition, studies have focused on strengthening the adductors, hip flexors, or abdominal muscles. Recent investigations have used an eccentric-biased exercise (Copenhagen Adduction Exercise [CAE]) that promotes functional and architectural adaptations in the muscle tissue, though its effect on injury risk reduction is unknown.
View Article and Find Full Text PDFObjectives: To assess the relationship between history of past season groin pain and current pain during the five-second squeeze test (5SST) with groin function and adductor strength in rink hockey players.
Design: Cross-sectional.
Setting: First (Ok Liga), Second (Plata) and third division (Bronce) clubs.