Publications by authors named "O D Slayden"
Article Synopsis
- Females with endometriosis show altered peristaltic and ciliary functions, prompting a study on rhesus macaques to assess the role of specific proteins related to these functions.
- The research focused on adenylate kinase 7 (AK7), forkhead protein box J1 (FOXJ1), and Anoctamin 1 (ANO1), with findings indicating that ANO1 expression is significantly reduced in both affected monkeys and ampullary segments treated with peritoneal fluid from endometriosis cases.
- The study suggests that lower levels of ANO1 may contribute to a particular form of infertility linked to endometriosis, emphasizing its potential importance in oviduct function.
In this brief review, we discuss our efforts to validate nanoplatforms for imaging and treatment of endometriosis. We specifically highlight our use of nonhuman primates and primate tissues in this effort. Endometriosis is a painful disorder of women and nonhuman primates where endometrium-like tissue exists outside of the uterus.
View Article and Find Full Text PDFPurpose: Endometriosis is an estrogen-dependent disorder of menstruating primates where tissues similar to the inner lining of the uterus exist "ectopically" outside of the uterus. The ectopic endometrium, like the endometrium within the uterus, expresses estrogen receptors (ER) and progesterone receptors (PR) and undergoes hormone-dependent cell proliferation and bleeding each menstrual cycle. The goal of this study was to conduct abdominopelvic positron emission tomography (PET) scans with computed tomography (CT) imaging of rhesus macaques (Macaca mulatta) using radiotracers that target ER and PR [16α-[F]fluoroestradiol (FES) and 12-[F]fluoro-furanyl-nor-progesterone (FFNP)] in individuals with and without endometriosis.
View Article and Find Full Text PDFA protocol for creating endometriosis in rhesus macaques (Macaca mulatta).
J Med Primatol
December 2023
Background: Endometriosis is the presence of endometrium-like tissue outside the uterine cavity. An experimental model of endometriosis has been created in the baboon by the transcervical collection and laparoscopic inoculation of menstrual endometrium. Macaques are the preferred model for pharmaceutical development, but the complex anatomy of the macaque cervix makes the baboon method impractical.
View Article and Find Full Text PDFProblem: Anovulatory infertility is commonly associated with hyperandrogenemia (elevated testosterone, T), insulin resistance, obesity, and white adipose tissue (WAT) dysfunction associated with adipocyte hypertrophy. However, whether hyperandrogenemia and adipocyte hypertrophy per se induce a proinflammatory response is unknown.
Method Of Study: Young adult female rhesus macaques were exposed to an obesogenic Western-style diet (WSD) in the presence of elevated circulating testosterone (T+WSD) or a low-fat control diet with no exogenous T.