[Myasthenic syndrome in a patient with end-stage amyotrophic lateral sclerosis].

Amyotrophic lateral sclerosis (ALS) and myasthenia gravis are diseases with similar clinical features but different prognosis and approach to treatment. It is possible as an extremely rare combination of these diseases, as well as myasthenia gravis with signs of ALS (MuSK-positive), as well as ALS, accompanied by myasthenic syndrome. Latter option is the most common.

[The association of gamma-synuclein autoantibodies with the polymorphism in exon 4 of the coding gene].

Aim: To analyze the polymorphism in exon 4 of the gamma-synuclein gene (SNCG) in patients with autoantibodies against the gamma-synuclein protein.

Material And Methods: To identify autoantibodies against gamma-synuclein, the serum from patients with chronic cerebral ischemia and cervical osteochondrosis was used. All patients were women of the Slavic ethnic group, mean age 61±5 years.

[Inhibitors of CNS regeneration, their physiological role and participation in pathogenesis of diseases].

The review is devoted to axon growth inhibitors in the CNS, including a physiological role of myelin-associated proteins (Nogo-A, MAG, OMgp) and their involvement in the pathogenesis of various diseases (spinal injuries, stroke, neurodegenerations).

[Clinical polymorphism of amyotrophic lateral sclerosis].

Aim: To clarify clinical polymorphism of amyotrophic lateral sclerosis (ALS).

Material And Methods: The study was based on records of a hospital personalized register. Ninety-four patients, aged from 25 to 81 years, diagnosed with ALS according to El Escorial criteria were included.

[Dimebon delays the onset of symptoms of FUS-proteinopathy in transgenic mice].

Aim: To evaluate an effect of dimebon on the onset of symptomatic stage in FUS.1-513 transgenic mice - a new genetic model of neurodegeneration, and to study the dynamics of disease progression in the terminal stage.

Material And Methods: The study was carried out on males of line FUS1-513 with the contribution of genes from CD1 strains.