[Heterogeneity and possible structure of mesenchymal stromal cell population].

Mesenchymal stromal cells (MSC) represent a heterogeneous population of cells that differ in morphology, phenotype, ability to grow and differentiate, and other properties. Differences between MSC are related in part to the influence of their microenvironment. However, the heterogeneity of these cells also is due to their parent-progeny relationship.

[Cellular composition and regulatory function of fetal liver stroma].

Hematopoietic differentiation and formation of hepatic tissue both take place in mammalian liver during its prenatal development. Hematopoietic and hepatic stem cells self-renew, proliferate and differentiate within specific microenvironment that is organized by stromal elements. Stroma of developing liver consists of different cell populations such as mesenchymal stromal cells, Ito cells, portal fibroblasts and myofibroblasts, vascular endothelial and smooth muscle cells, cells undergoing epithelial-to-mesenchymal transition.

[Spontaneous and induced myogenesis in cell culture from rat fetal liver].

Fetal liver stroma consists of different cell populations that are studied insufficiently. We have found skeletal muscle precursors that express MyoD in liver of 17 day and 20 day rat fetuses. Spontaneous myotube formation was observed in primary cultures of liver cells of 15, 17 and 20 day fetuses.

[Comparative study of clonal growth and differentiation of mesenchymal stromal cells from rat fetal liver at different developmental stages].

Fetal liver during period of its hematopoietic activity contains mesenchymal stromal cells (MSC) that are known to play a major role in establishing hematopoietic microenvironment. These cells are capable of clonal growing and multilineage differentiation, but only limited data exist about changes in their properties during prenatal development. We compared cloning efficiency of MSC from liver of 14, 16 and 20 day rat fetuses and evaluated their potentials to in vitro osteo- and adipogenesis and in vivo chondrogenesis after whole organ ectopic transplantation.