Fetal progenitor cells for treatment of chronic limb ischemia.

Objectives: This study investigated the therapeutic potential of fetal progenitor cells (FPCs) in the treatment of chronic non-healing wounds and ulcers associated with chronic limb ischemia (CLI). The research aimed to elucidate the mechanism of action of FPCs and evaluate their efficacy and safety in CLI patients.

Methods: The researchers isolated FPCs from aborted human fetal liver, brain, and skin tissues and thoroughly characterized them.

[Dynamics of ultrastructural changes in the capillary endotheliocytes of the ischemic extremity in rats after transplantation of hematopoietic stem cells from the human fetal liver].

Experimental investigation was performed on the rats, in which the extremity ischemia was simulated to assess the application efficacy of hemopoietic stem cells, obtained from the human fetus liver, with the objective of angiogenesis activation. The perspective of the method application with the objective to stimulate the angiogenesis processes de novo in ischemia of the extremity, was studied, using the electron microscopy methods.

[Effect of allotransplantation of embryonic pluripotent progenitor cells on dynamics of systemic arterial blood pressure in spontaneously hypertensive rats].

The influence of embryonic pluripotent progenitor cells on the dynamics of the systemic arterial pressure was examined in rats with genetically determined arterial hypertension. It has been established that the single intravenous administration of the embryonic pluripotent and progenitor cells to spontaneously hypertensive rats in the amount of 5 x 10(7) ml lead to the lowering of the systemic arterial pressure for one month.

[Differences in differential diagnosis between acute mesenterial lymphadenitis and appendicitis in children].

The thermal streams intensity (THSI) from definite points of anterior abdominal wall in children with an acute mesenterial lymphadenitis (AML) and an acute appendicitis (AA) were determined. It was established, that in right inguinal region THSI in AA was in 4.06 times higher than in AML, in paraumbilical region--THSI was in 2.

[Characteristics of kidney function before and after surgical treatment of obstructive pyelonephritis in children].

Using the clearance method in children with obstructive pyelonephritis were investigated the changes of the renal excretory and ion-regulating functions before and after the operation. After performance of the operation the renal function had worsened.