Paracrine role of endothelial IGF-1 receptor in depot-specific adipose tissue adaptation in male mice.

During recent decades, changes in lifestyle have led to widespread nutritional obesity and its related complications. Remodelling adipose tissue as a therapeutic goal for obesity and its complications has attracted much attention and continues to be actively explored. The endothelium lines all blood vessels and is close to all cells, including adipocytes.

Navigating UK internal medicine training applications: 10 essential tips.

Internal medicine training applications in the UK have become increasingly competitive. This article provides ten tips for optimizing internal medicine training applications covering portfolio development, teaching experience, project selection, and interview preparation. We outline strategies for maximizing application scores through efficient resource allocation, effective project selection, and structured interview preparation.

Intraoperative Predictors of Salvage in Infected Breast Implants: A Retrospective Study.

Background: Infectious complications associated with implant-based breast reconstruction (IBBR) can be devastating and may lead to reconstructive failure. While there are known demographic risk factors for reconstructive failure, few studies have identified intraoperative findings that predict failure after attempted salvage.

Objectives: The objective of this study was to identify intraoperative findings in infected breasts that may be predictive of implant failure.

Dexterity assessment of hospital workers: prospective comparative study.

Objectives: To compare the manual dexterity and composure under pressure of people in different hospital staff roles using a buzz wire game.

Design: Prospective, observational, comparative study (Tremor study).

Setting: Leeds Teaching Hospitals NHS Trust, Leeds, UK, during a three week period in 2024.

Joint British Societies' position statement on cardiology training in the United Kingdom.

Cardiology training in the UK is facing significant challenges due to a range of factors. Recent curriculum changes have further compounded this issue and significantly risk the ability to produce adequately trained consultants capable of managing patients with increasingly complex cardiovascular disease. The introduction of mandatory dual accreditation in general internal medicine (GIM) alongside cardiology, by design, results in significantly reduced training opportunities, including procedural and subspecialty exposure.