[Changes in the lysosomal apparatus of the neutrophilic leukocytes in the disseminated coagulation syndrome].

The dependent of DIC development on lysosomal apparatus neutrophils activity was founded. The most severe changes in hemostasis system were registered in the period of maximum acid phosphatus activity.

[The effect of hypoxia of different origins and of the degree of its severity on the functional activity of the lysosomal apparatus].

We studied the activity of lysosomal enzymes (acid phosphatase and cathepsine D) and the status of lysosomal membranes of the liver, lung, heart and brain tissues of the male adult rats under acute hypoxia. We found that disturbances of lysosomal membranes permeability in these organs depend on the tissues hypoxia development, not yet on the genesis of hypoxic state. The lysosomal enzymes activation depends on the heaviness of the hypoxic influence.

[The effect of the lysosomal function of circulating neutrophils on hemostasis and on the morphological changes in the internal organs in the disseminated intravascular coagulation syndrome].

Development of experimental the syndrome of disseminated intravascular coagulation, DIC syndrome, in organism laboratory animals from affect preparation "EFA-2" by accompanied increase quantity of neutrophiles circulations, modifications of the lysosomal apparatus of neutrophiles the activity of the serum acid phosphatase increased, characteristic damage on hemostasis system and typical alteration in some organs. As a result limitation of number of neutrophiles was achieved of suppression, of granulocytopoiesis by means "Myelosan" pharmacy, did not increase activity in blood serum solution lysosomal enzyme of neutrophils and not development in organism DIC syndrome. Made conclusion, the neutrophils have influence of promotion generalization DIC syndrome.