Femoral Neck Fracture Non-Union: Treatment with Bone Marrow Concentrate, Demineralized Bone Matrix, and Morselized Allograft and Angular Stable Fixation. Report of 2 Cases.

Introduction: Femoral neck fractures in young adults, particularly Pauwels' 3 fractures with angles exceeding 70°, pose challenges in determining optimal surgical interventions due to limited clinical trial data. Complications such as avascular necrosis, non-union, and shortening hinder the healing process. Existing fixation methods, including multiple cannulated screws and sliding hip screws, have shown non-union rates of nearly 9% in young patients.

FixThePig: a custom 3D-printed femoral intramedullary nailing for preclinical research applications.

Background: Critical-size bone defects (CSBDs) pose significant challenges in clinical orthopaedics and traumatology. Developing reliable preclinical models that accurately simulate human conditions is crucial for translational research. This study addresses the need for a reliable preclinical model by evaluating the design and efficacy of a custom-made 3D-printed intramedullary nail (IMN) specifically for CSBDs in minipigs.

Case report: Personalized triple phage-antibiotic combination therapy to rescue necrotizing fasciitis caused by Panton-Valentine leukocidin-producing MRSA in a 12-year-old boy.

Maximal standard-of-care (SOC) management could not stop the life-threatening progression of a necrotizing fasciitis induced by Panton-Valentine Leukocidin-producing Methicillin-Resistant (MRSA) in a 12-year-old boy. Multi-route phage therapy was initiated along with antibiotics against and , eventually leading to full recovery with no reported adverse events.

HLA Awareness in tissue decellularization: A paradigm shift for enhanced biocompatibility, studied on the model of the human fascia lata graft.

Last twenties, tissue engineering has rapidly advanced to address the shortage of organ donors. Decellularization techniques have been developed to mitigate immune rejection and alloresponse in transplantation. However, a clear definition of effective decellularization remains elusive.