Publications by authors named "O Cores Calvo"
Article Synopsis
- - The Integrator complex consists of at least 13 conserved proteins that interact with RNA polymerase II to regulate snRNA processing and gene expression.
- - This study highlights the role of Integrator subunit 6 (INTS-6) in the DNA damage response, specifically its necessity for forming RAD-51 foci after X-ray radiation exposure.
- - The presence of INTS-6 is also shown to be essential for the phosphorylation of CDK-1 at Tyr-15, contributing to our understanding of how the Integrator complex participates in DNA repair processes.
Sub1 (ScSub1) has been defined as a transcriptional stimulatory protein due to its homology to the ssDNA binding domain (ssDBD) of human PC4 (hPC4). Recently, PC4/Sub1 orthologues have been elucidated in eukaryotes, prokaryotes, and bacteriophages with functions related to DNA metabolism. Additionally, ScSub1 contains a unique carboxyl-terminal region (CT) of unknown function up to date.
View Article and Find Full Text PDFHeterodimerization of RNA binding proteins Nrd1 and Nab3 is essential to communicate the RNA recognition in the nascent transcript with the Nrd1 recognition of the Ser-phosphorylated Rbp1 C-terminal domain in RNA polymerase II. The structure of a Nrd1-Nab3 chimera reveals the basis of heterodimerization, filling a missing gap in knowledge of this system. The free form of the Nrd1 interaction domain of Nab3 (NRID) forms a multi-state three-helix bundle that is clamped in a single conformation upon complex formation with the Nab3 interaction domain of Nrd1 (NAID).
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