Publications by authors named "O Clavero"
: Sinonasal exophytic papillomas (SNEP) are benign tumours arising from nasal mucosa. Human papillomavirus (HPV) infection seems to be related to the aetiology of a fraction of SNEP cases. SNEP presentation can be focal (FSNEP) or diffuse (DSNEP), but factors related to focal or diffuse presentation have not yet been well ascertained.
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- Mixed carcinomas, which represent about 10% of penile carcinomas, consist of multiple distinct histological subtypes, categorized by the World Health Organization (WHO) into two groups based on their HPV association.
- The study aimed to detect HPV genotypes in these mixed tumors, revealing a higher HPV positivity rate (46%) in carcinomas with warty/basaloid features compared to a low rate (7%) in non-warty/basaloid types.
- HPV16 was the most commonly identified genotype (65%), and the presence of HPV-associated morphology above 20% in mixed tumors is critical for classification as HPV-associated, in accordance with WHO guidelines.
Article Synopsis
- * The study involved over 1,100 patients across 19 hospitals, revealing that men made up 82% of diagnoses, with an upward trend in HPV-driven oropharyngeal cancers increasing from 44.2% to 51.7% over the decade.
- * HPV genotypes linked to the 9-valent HPV vaccine accounted for 95.2% of HPV-driven H
Detection of variable genotypes in common human papillomavirus-associated invasive penile squamous cell carcinomas: a study of 177 human papillomavirus-positive cases.
Hum Pathol
September 2023
Article Synopsis
- HPV is found in 30-50% of invasive penile cancers, often linked to specific cell types like basaloid and warty carcinomas, indicating diversity in genetic behavior.
- A study of 177 HPV-positive cases revealed 19 genotypes, with a high prevalence of high-risk types (96%) and HPV16 being the most common.
- The findings suggest that current HPV vaccinations would cover 93% of cases, with distinct patterns in genotype distribution—HPV16 being more frequent in basaloid cancers compared to warty forms, highlighting their unique characteristics.
There are few pathologic or molecular studies of penile precancerous lesions, and the majority refers to lesions associated with invasive carcinomas. Penile Intraepithelial Neoplasia (PeIN) is classified in two morphologically and distinctive molecular groups, non-HPV and HPV-related with special subtypes. The primary purpose of this international series was to classify PeIN morphologically, detect HPV genotypes and determine their distribution according to PeIN subtypes.
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