Publications by authors named "O Charara"
Clinical course and cost assessment of infants with a first episode of acute bronchiolitis presenting to the emergency department: Data from the GUERANDE clinical trial.
Pediatr Pulmonol
December 2021
Introduction: Bronchiolitis is the leading cause of hospitalization for infants but its economic burden is not well documented. Our objective was to describe the clinical evolution and to assess the 1-month cost of a first episode of acute bronchiolitis presenting to the emergency department (ED).
Methods: Our study was an epidemiologic analysis and a cost study of the cohort drawn from the clinical trial GUERANDE, conducted in 24 French pediatric EDs.
Aim: To assess the prevalence of clinically urgent intracranial pathology (CUIP) in children visiting the emergency department with a complex febrile seizure (CFS).
Methods: Retrospective cohort review. We analysed the visits of patients for a CFS from January 2007 to December 2011 in seven paediatric emergency departments.
Article Synopsis
- Acute bronchiolitis is a major reason for hospitalizations in infants, and previous research suggested limited effectiveness of nebulized hypertonic saline (HS) treatment in emergency settings.
- The GUERANDE study was a large, multicenter clinical trial that aimed to determine if nebulized HS could reduce hospital admissions for infants experiencing their first acute bronchiolitis episode.
- Results showed no significant difference in hospital admission rates between the HS group (48.1% admitted) and the normal saline (NS) group (52.2% admitted), although the HS group did show greater improvement in respiratory distress symptom scores.
Study Objective: We assess the prevalences of bacterial meningitis and herpes simplex virus meningoencephalitis (HSV-ME) in children with a complex febrile seizure and determine these prevalences in the subgroup of children with a clinical examination result not suggestive of meningitis or encephalitis.
Methods: This multicenter retrospective study was conducted in 7 pediatric emergency departments (EDs) in the region of Paris, France. Visits of patients aged 6 months to 5 years for a complex febrile seizure from January 2007 to December 2011 were analyzed.
Objectives: National and international guidelines are very heterogeneous about the necessity to perform a lumbar puncture (LP) in children under 12 months of age with a first simple febrile seizure. We estimated the risk of bacterial meningitis in children aged 6 to 11 months with a first simple febrile seizure.
Methods: This multicenter retrospective study was conducted in seven pediatric emergency departments (EDs) in the region of Paris, France.