Publications by authors named "O Cevik"
Introduction: High mortality and morbidity of neonates with necrotizing enterocolitis (NEC) necessitates the investigation of novel therapies to improve outcomes. It was aimed to elucidate the potential therapeutic effect of estrogen receptor agonists on NEC-induced intestinal and brain injury in rats.
Methods: Sprague-Dawley pups of both sexes were separated from their mothers at postnatal 5 d.
Background: Intrinsic apoptosis plays a critical role in immune defense and inflammation. Its dysregulation is involved in various chronic diseases. The B-cell lymphoma 2 (Bcl-2) family primarily mediates this mitochondrial pathway.
View Article and Find Full Text PDFObjective: In our study, the protective effect of dodder plant extract against encephalopathy induced by cholestatic liver disease model was investigated.
Methods: Spraque Dawley rats were used in the study. For the cholestatic liver disease model, the bile duct ligation (BDL) was applied.
Designing new compounds from existing chemotherapeutic drugs to enhance inhibitory effects on tumor cells while overcoming multidrug resistance is one of the important strategies for new drug discovery in medicinal chemistry. A new series of urea and thiourea derivatives based on Lenalidomide as potential anticancer agents have been designed and synthesized. In vitro anticancer activity assay against Caki cancer cells and HUVEC endothelial cells revealed that 1-(4-methylphenyl)-3-[2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl]urea (11) exhibited the highest anticancer activity and selectivity in the series with IC values of 9.
View Article and Find Full Text PDFArticle Synopsis
- Nanotechnology has gained attention in biomedical applications over the last decade, particularly through the use of environmentally friendly green synthesis of metal and metal oxide nanoparticles (NPs), which are cost-effective and safe.
- The study focuses on synthesizing zinc oxide nanoparticles (ZnONPs) and metal-doped ZnONPs (with Mg and Ag) using plant extracts rich in phytochemicals, which serve as reducing and stabilizing agents.
- Characterization of the synthesized NPs revealed their size and shape through techniques like SEM and DLS, while also showing antibacterial activity against both Gram-positive and Gram-negative bacteria.