Publications by authors named "O Cazzalini"
Background And Aim: Resveratrol (RSV), is a stilbene-based compound exerting wide biological properties. Its analogue 4,4'-dihydroxy--stilbene (DHS) has shown improved bioavailability and antiproliferative activity and . One of the hypotheses on how resveratrol works is based on SIRT1 activation.
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- Asparaginase (ASNase) significantly improves treatment outcomes for pediatric Acute Lymphoblastic Leukemia (ALL), achieving remissions in about 90% of cases, but its effects on adult solid tumors are not well understood.
- In a study on three adenocarcinoma cell lines (A549, MCF-7, and 786-O), it was found that A549 and 786-O cells responded differently to ASNase treatment, with A549 showing a typical response while 786-O displayed alterations in cell cycle phases and dysfunctional DNA synthesis.
- The findings suggest unique mechanisms of ASNase action in solid tumors, particularly in the 786-O cells, indicating a different response than what is seen in leukemic
Background: DNA-Damaged Binding protein 2 (DDB2) is a protein involved in the early step of Nucleotide Excision Repair. Recently, it has been reported that DDB2 is involved in epithelial-to-mesenchymal transition (EMT), key process in tumour invasiveness and metastasis formation. However, its role is not completely known.
View Article and Find Full Text PDFAn important biomarker of oxidative damage in cellular DNA is the formation of 7,8-dihydro-8-oxo-2'-deoxyguanosine (8-oxodG). Although several methods are available for the biochemical analysis of this molecule, its determination at the single cell level may provide significant advantages when investigating the influence of cell heterogeneity and cell type in the DNA damage response. to.
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