Implications of a two-stage clonal expansion model to indoor radon risk assessment.

Spreadsheet macro programs for calculations of exact hazard and probability of having contracted cancer were used to study the implications of the lung cancer model of Moolgavkar et al. Excess lifetime risk ELR and loss of life expectancy LLE were calculated from the annual values of hazard and probability, using published life tables. The influence of various factors on ELR and LLE was studied, as well as the lifetime risk projection in epidemiological studies.

Indoor radon exposure and risk of lung cancer: a nested case-control study in Finland.

Background: Inhaled radon has been shown to cause lung cancer among underground miners exposed to very high radon concentrations, but the results regarding the effects of residential radon have been conflicting.

Purpose: Our aim was to assess the effect of indoor radon exposure on the risk of lung cancer.

Methods: To investigate this effect, a nested case-control study was conducted in Finland.

Lymphocyte beta-2-adrenoceptors and plasma catecholamines in fetal hypoxia.

Conclusive evidence has been furnished that the beta 2-adrenoceptor density in circulating lymphocytes is related to that of beta 2-adrenoceptors in tissues from the same subjects. This study was designed to evaluate the effect of fetal hypoxia on lymphocyte beta 2-adrenoceptor density. The material consisted of 8 hypoxic newborns, 4 delivered by vacuum extraction and 4 by Caesarean section, after approximately 10 h parturition.

Prevalence, incidence, and estimated life-time risk of cervical human papillomavirus infections in a nonselected Finnish female population.

The authors derived prevalence and incidence figures for cervical human papillomavirus (HPV) infections in an unselected Finnish population of women aged 22. This paper is an epidemiologic study utilizing the mass-screening program that has been conducted in Finland for cervical cancer since the early 1960s. The authors estimated the lifetime risk of cervical HPV infections based on the figures in this program and on those derived from a random sample of 2,084 (out of 28,861) routine Papanicolaou (Pap) smears examined in their laboratory.

Lymphocyte beta 2-adrenoceptor density during menstrual cycle and pregnancy, in delivery and puerperium.

Lymphocyte beta 2-adrenoceptor density was determined in 11 women during the normal menstrual cycle and 15 women during normal pregnancy. No significant difference in lymphocyte beta 2-adrenoceptor density was established in this follow-up study during the menstrual cycle or pregnancy. Lower lymphocyte beta 2-adrenoceptor density was established just after delivery and in puerperium compared with that during pregnancy.