Publications by authors named "O Capitain"
Background And Aims: Bevacizumab-based chemotherapy is a recommended first-line treatment for metastatic colorectal cancer (mCRC). Robust biomarkers with clinical practice applicability have not been identified for patients with this treatment. We aimed to evaluate the prognostic yield of serum mid-infrared spectroscopy (MIRS) on patients receiving first-line bevacizumab-based chemotherapy for mCRC.
View Article and Find Full Text PDFAdapted EXTREME regimen in the first-line treatment of fit, older patients with recurrent or metastatic head and neck squamous cell carcinoma (ELAN-FIT): a multicentre, single-arm, phase 2 trial.
Lancet Healthy Longev
June 2024
Background: A standard treatment for fit, older patients with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC) is yet to be established. In the previous EXTREME trial, few older patients were included. We aimed to evaluate the efficacy and tolerance of an adapted EXTREME regimen in fit, older patients with recurrent or metastatic HNSCC.
View Article and Find Full Text PDFArticle Synopsis
- There is currently no reliable biomarker for predicting the effectiveness of EGFR inhibitors in head and neck squamous cell carcinoma (HNSCC), leading researchers to investigate afatinib, a promising treatment.
- In a trial with 61 patients, afatinib showed a high metabolic response, with responders demonstrating specific biomarker expressions (higher pERK1/2 and lower pHER4 and pRB1 levels).
- Further analysis indicated that responders had more tumor-infiltrating B cells, while non-responders had an overrepresentation of NF-kappa B signaling in their gene expression, suggesting potential new biomarkers for afatinib efficacy that require more research.*
Aims: The exposure-response relationship of bevacizumab may be confounded by various factors, including baseline characteristics, time-dependent target engagement and recursive relationships between exposure and response, requiring effective mitigation. This study aimed to investigate the exposure-response relationships of bevacizumab in metastatic colorectal cancer (mCRC) patients while mitigating potential biases.
Methods: Bevacizumab pharmacokinetics was described using target-mediated drug disposition modelling.
Purpose: To evaluate tipapkinogene sovacivec (TG4001), a viral immunotherapeutic vaccine expressing human papillomavirus (HPV)16 E6/E7 non-oncogenic proteins and IL-2, in combination with avelumab in HPV16+ cancer patients.
Patients And Methods: In this open-label, phase Ib/II, multicenter study, HPV16+ advanced cancer patients received subcutaneous TG4001 at two dose levels (DL) in phase Ib and at the recommended phase II dose (RP2D) in phase II weekly for 6 weeks, then every 2 weeks (q2Wk) until 6 months, thereafter every 12 weeks, in combination with avelumab q2Wk starting from day 8. Exploratory end-points included immunomonitoring from sequential tumour and blood samples.