Publications by authors named "O Cabalero"
Article Synopsis
- Mesial temporal lobe epilepsy related to hippocampal sclerosis (MTLE-HS) may have genetic links to the prion protein (PrP(c)) gene, which affects neuronal excitability and seizure sensitivity.
- A study compared the PRNP gene sequences of 100 patients with surgically treated MTLE-HS to 180 healthy controls, revealing a significant presence of the Asn171Ser variant in patients but not in controls.
- The Asn171Ser variant was found to increase the likelihood of continued seizures post-surgery, with 91.8% of normal allele carriers being seizure-free at 18 months, compared to only 68.2% of those with the variant, indicating a potential impact on surgical outcomes.
